Re: Zhoubný melanom a těhotenství

To je smula. Pokud hovoris AJ, tak na www je spousta informaci. Mela by jsi si najit primo specialistu na Melanoma. Urcite to konzultuj z dalsim doktorem. Musis brat v potaz reprodukcni vek.

have placed some information from the NIH below. It is always a hard decision with imperfect data to guide us. At stage 1 you might be okay but I would still discuss it with a melanoma specialist. You have to take your own reproductive age into consideration. If you are in your late 20""s or early 30""s you have time. If you are in your mid thirties and beyond, you need to take overall fertility into consideration.

Hope it helps,

Kevin



Should women who previously were diagnosed with
melanoma avoid pregnancy?

The issue here is whether pregnancy activates micrometastatic
disease. There is no convincing evidence
that pregnancy activates or stimulates dormant micrometastatic
disease, although anecdotal case reports
certainly suggest that this may happen in some cases. One
of the difficulties in addressing this question is that it is
impossible to know prospectively which patients are harboring
micrometastases. One author noted similar fiveand
ten-year survival rates for 115 patients who were
pregnant with melanoma compared with 330 female
melanoma patients who were never pregnant during or after
their diagnosis."" The pregnant group, however, had a
higher frequency of lymph node involvement at the time
of diagnosis. A better survival was actually noted for 71
patients who were pregnant within a year before or five
years after a diagnosis of melanoma, but the control group
consisted of only 31 women who did not get pregnant
during a similar interval and who actually had higher
stage disease.47 In another study, women diagnosed with
melanoma before getting pregnant were compared with
women diagnosed after completing all pregnancies.39 The
latter group actually appeared to do worse at five years,
although statistical comparison was not provided. In a retrospective
study conducted at Duke University, 43
women with stage I melanoma who became pregnant
within the next five years had prognoses similar to those
of 337 women who did not get pregnant, both in terms of
relapse and disease-free survival.9
There is no evidence that nulliparous women as a
group differ from parous women as a group, in terms of
prognosis from the time of a subsequent diagnosis of
melanoma while pregnant. In a study that compared 85
women diagnosed with melanoma before their first pregnancy
with 143 women who had completed all pregnancies,
melanoma developed in 68 between pregnancies and
in 92 during pregnancy, and there was no difference in
these groups.39 Two other small studies also found no difference
in prognosis for nulliparous as opposed to parous
women,4M42 although the studies were small in scope. The
only trials that address the issue of the importance of subsequent
pregnancy on prognosis have failed to identify
parity as an important variable in multivariate analysis.39
In the absence of definitive data, many authorities have
recommended that women avoid pregnancy for two to
five years after a diagnosis of melanoma, mainly because
that is the time period during which most recurrences are
diagnosed.""944149 In one study, such patients who did become
pregnant were actually used as controls to compare
with patients who were being diagnosed with melanoma
for the first time while pregnant.37

Should women who previously were diagnosed with
melanoma during a pregnancy avoid subsequent pregnancy?
Historically, there has been great concern regarding
the risk of subsequent pregnancy in women who were initially
diagnosed with melanoma during a previous pregnancy,
based on the presumption that these melanomas in
particular may be influenced adversely by growth factors
and hormones secreted during pregnancy. Earlier observers
felt strongly that pregnancy worsened the prognosis
in this group of patients.2549 There is no objective
evidence that this group is at higher risk with subsequent
pregnancy, however. Despite this, the consensus is to recommend
the deferral of subsequent pregnancy for two to
three years in women in whom a primary melanoma developed
during pregnancy.7

Is there a risk of transplacental metastases to the fetus:?

There definitely is a risk of transplacental transmission
of melanoma from mother to fetus, but fortunately
this risk is low. Placental involvement itself is indicative
of widespread hematogenous dissemination in the
mother, but placental involvement does not necessarily
mean that the newborn baby will have melanoma. Of 35
cases of placental or fetal involvement with cancer following
pregnancy, one study found that 11 were due to
melanoma, the most common cancer associated with this
phenomenon, followed by leukemia or lymphoma. Of
the 11 melanoma patients, the placenta was involved in 7
and the fetus in 6. Two of the infants with melanoma underwent
spontaneous regression of disease after delivery.
It has been suggested that only 25% of infants with placental
metastatic melanoma will actually die of metastatic
melanoma, and it is almost always manifest at the time
of delivery and then fails to regress spontaneously after
delivery. The implications of these observations are that
women diagnosed with metastatic melanoma during
pregnancy need not abort their fetus out of a fear of
transplacental spread, and active therapy for a fetus born
in the setting of placental metastases is not warranted.